Blog
Pressure injury. How to prevent and what use
The most vulnerable areas include bony prominences such as the heels, sacrum, and elbows. The fundamental aspect of preventing pressure injuries lies in frequent repositioning and movement to alleviate prolonged pressure on specific areas of the body.
Diabetic Peripheral Neuropathy on DFUs
This condition results from prolonged hyperglycemia, leading to nerve damage that impairs sensation, autonomic function, and motor control in the lower extremities. focusing on early detection, comprehensive foot care, and advanced wound management strategies, healthcare providers can improve the quality of life for diabetic patients and reduce the burden of lower extremity complications.
Multidrug-resistant Pseudomonas aeruginosa
The presence of MDR Pseudomonas aeruginosa in wounds can severely delay healing, increase morbidity, and limit treatment options, making effective management strategies critical in clinical settings. The burden of MDR Pseudomonas aeruginosa in wound care underscores the need for a multifaceted approach that combines effective antimicrobial strategies, rigorous infection control measures, and ongoing research into alternative therapies
Fungal nail infection treatment
Fungal nail infections affect the toenails and fingernails. They are caused by dermatophytes, yeasts, or molds that invade the nail bed and plate, leading to discoloration, thickening, and brittleness. Early intervention is key to preventing complications and improving treatment success. Consulting a healthcare professional for proper diagnosis and treatment recommendations ensures the most effective approach for each individual case.
Iron and wound healing
Iron is an essential micronutrient in wound healing, in collagen synthesis, cellular proliferation, and tissue repair. Deficiencies in iron can result in delayed healing, increased risk of infection, and chronic wound formation. By ensuring adequate iron intake through diet, supplementation, and medical management, healthcare providers can improve patient outcomes and promote efficient wound healing.
Carbapenem-resistant Enterobacteriacea
Carbapenem-resistant Enterobacteriaceae (CRE) are a group of highly drug-resistant bacteria that pose a significant challenge in wound care, particularly in patients with chronic wounds, surgical wounds, and diabetic foot ulcers. Their resistance to most antibiotics makes treatment difficult, increasing the risk of poor healing and systemic infections.
Compression Therapy for the Treatment of Wounds on the Lower Limb
Compression therapy is a non-invasive, effective treatment that improves venous return, reduces edema, and enhances wound healing. Compression therapy is an essential treatment for managing lower limb wounds, particularly those related to venous insufficiency and chronic edema.
Prevention of Venous Leg Ulcer
Preventing venous leg ulcers is essential for improving patients’ quality of life and reducing healthcare costs associated with chronic wound management. Effective prevention strategies focus on improving venous circulation, reducing risk factors, and maintaining skin integrity.
The importace to have glucose contol in wound care for diaebtic foot ulcer
Diabetes mellitus is a global health concern, affecting millions of individuals and increasing the risk of serious complications, including diabetic foot ulcers (DFUs). Proper management of blood sugar levels is essential for enhancing the body’s natural healing mechanisms, preventing infections, and reducing the risk of complications.
Diagnosis of Osteomyelitis in Diabetic Foot Ulcer
One of the most serious complications of a DFU is osteomyelitis, a bone infection that can result in delayed healing, extensive tissue damage, and even limb amputation if left untreated. Early and accurate diagnosis of osteomyelitis in diabetic foot ulcers is crucial for effective management and improved patient outcomes.
Matrix metalloproteinases and other inflammatory mediators in wuond healing process
A critical component of this process is the regulation of inflammatory mediators, including matrix metalloproteinases (MMPs), cytokines, and growth factors. Matrix metalloproteinases and inflammatory mediators are critical to the wound healing process, regulating inflammation, ECM remodeling, and tissue repair
The importance of caregiver in pressure injury prevention
Pressure injuries, also known as pressure ulcers or bedsores, are a significant health concern, particularly for individuals with limited mobility, chronic illnesses, or those who are bedridden. Caregivers, whether family members, nursing staff, or professional aides, play a vital role in preventing pressure injuries through essential actions
Biofilm and wound care: What to do?
Biofilm is a structured community of bacteria and other microorganisms encased in a protective extracellular matrix. This matrix makes the bacteria highly resistant to antibiotics and the body’s immune defenses, leading to persistent infections and delayed healing.
Signs and Symptoms of Wound Infection
Recognizing the early signs of wound infection is crucial for prompt treatment and preventing complications. To reduce the risk of infection, keep wounds clean and covered, change dressings regularly, wash hands before touching the wound, and follow healthcare instructions carefully.
Hypergranulation Tissue and Wound Care
Hypergranulation tissue is an overgrowth of granulation tissue that extends above the level of the surrounding skin. This tissue appears as raised, red, and often moist, and it can be tender to the touch. Hypergranulation tissue can be a challenging complication in wound healing, but with appropriate care and management, it can be controlled.
Hidradenitis suppurativa: new biological treatment
HS is a debilitating condition marked by recurring inflammation of the hair follicles and sweat glands, leading to abscess formation and, eventually, scarring. It affects both men and women, but is most commonly seen in women and tends to develop after puberty. The introduction of biologics has brought significant improvements in the management of HS.
Leg ulcer: reasons and treatment
Leg ulcers are open wounds on the lower limb. A chronic wound is an ulcer that takes more than four weeks to heal.
Nail Fungal infection
Fungal nail infections, also known as “onychomycosis,” are very common. These infections may cause nails to become discolored, thick, fragile, or cracked. The nail may also become separated from the nail bed.
MRSA skin infection
MRSA stands for methicillin-resistant Staphylococcus aureus, a type of bacteria that is resistant to several antibiotics. MRSA infections mainly affect people who are staying in hospitals. They can be serious, but can be treated with antibiotics that work against MRSA.
Skin Bacterial Infections Causes, Symptoms, and Treatments
Skin bacterial infections are a common medical condition affecting millions of people worldwide. Various types of bacteria can cause skin infections. The most common culprits include Staphylococcus aureus, Streptococcus pyogenes, and Methicillin-resistant Staphylococcus aureus (MRSA).
Preventing Surgical Site Infections in Abdominal Surgery
These infections can lead to prolonged hospital stays, increased healthcare costs, and potential life-threatening complications for patients. Patients with certain risk factors, such as obesity, diabetes, immunosuppression, or prior infections, are more susceptible to developing SSIs. Preventing SSI in abdominal surgery requires a comprehensive approach that involves the entire surgical team, from preoperative planning to postoperative care
Different Types of Wound Dressings
Wound dressings play a crucial role in the management of wounds. significant advancements have been made in wound care technology, resulting in a diverse range of wound dressings tailored to specific wound types and stages of healing.
Pseudomonas Skin Infection Causes, Symptoms, Treatment, and Prevention
Pseudomonas skin infection is a type of bacterial infection caused by the pathogen Pseudomonas aeruginosa. This bacterium is commonly found in the environment, including soil, water, and plants. Pseudomonas skin infection can be a serious concern for individuals with compromised immune systems or open wounds. Awareness of the risk factors, symptoms, and prevention measures can aid in early diagnosis and effective treatment.
Chronic limb ischemia
Chronic limb ischemia (CLI) is a serious medical condition characterized by reduced blood flow to the extremities, most commonly the legs. If left untreated, can lead to severe pain, tissue damage, non-healing ulcers, and even limb amputation.
Pyoderma gangrenosum
Pyoderma gangrenosum (PG) is a rare and debilitating skin condition characterized by painful, rapidly spreading ulcers or sores. PG is a type of neutrophilic dermatosis, an inflammatory disorder that affects the skin and subcutaneous tissues. This disorder is not contagious and can affect individuals of any age, sex, or race, but it is most commonly seen in adults between the ages of 20 and 50.
PHMB Foam Dressing
Polyhexamethylene Biguanide (PHMB) is a versatile foam dressing that offers a multitude of benefits for patients and healthcare professionals. It is an effective biocide that disrupts the cell membranes of microorganisms. This action leads to the destruction of bacteria and fungi, preventing infections and promoting wound healing.
Super-oxidized Disinfectant Solution A Revolutionary Approach for Treating Chronic Wounds
Super-oxidized solutions are produced by subjecting a saline solution to an electrolysis process, creating a potent mixture of active oxidizing agents, including hypochlorous acid (HOCl) and free oxygen radicals. The resulting solution is antimicrobial, anti-inflammatory, and promotes wound healing.
Awarded Cavaliere dell’Ordine della Stella d’Italia
On July 3, 2025, I was deeply honored to receive the title of Cavaliere dell’Ordine della Stella d’Italia from the President of the Italian Republic. A recognition I dedicate to family, mentors, and all who support my cross-cultural journey.
Hyperbaric therapy for the treatment of necrotizing fasciitis
Necrotizing fasciitis is a rare but life-threatening soft tissue infection characterized by rapid, widespread destruction of the fascia and surrounding tissues. Hyperbaric oxygen therapy (HBOT) is a medical treatment that involves breathing pure oxygen in a pressurized environment. The rationale behind using hyperbaric therapy for necrotizing fasciitis lies in its ability to improve tissue oxygenation and reduce bacterial growth.
Lower Extremity Arterial Disease
Lower Extremity Arterial Disease (LEAD) is a common vascular disorder that affects the arteries supplying blood to the lower extremities, primarily the legs and feet. Several risk factors contribute to the development of LEAD, including smoking, diabetes, hypertension, dyslipidemia
Different kind of debridement
Debridement is a medical procedure used to remove damaged, infected, or dead tissue from a wound or ulcer to promote healing and prevent the spread of infection. several different types of debridement are available and it plays a crucial role in wound management and is vital for facilitating the body’s natural healing process.
Heal Symposium
On May 30th, 2025, we hosted an engaging workshop in Dubai focused on advanced wound care treatment.
Zinc in the wound healing
Zinc is an essential trace element found throughout the human body and is involved in over 300 enzymatic reactions. It plays a crucial role in cell division, protein synthesis, immune function, and wound healing. Whether administered orally as a dietary supplement or applied topically in ointments or dressings, zinc has proven benefits in promoting wound healing, reducing infection risk, and minimizing scarring
Wound management
Wound management is a critical aspect of medical care that revolves around the prevention, assessment, treatment, and healing of various types of wounds. Wound management often requires a multidisciplinary approach, involving collaboration between healthcare professionals such as wound care nurses, surgeons, infectious disease specialists, nutritionists, and physical therapists.
Managing Acute and Chronic Wound Pain
Managing acute and chronic wound pain is a crucial aspect of patient care, as it not only affects the individual’s physical comfort. The first step in managing wound pain is a thorough assessment. Healthcare professionals must consider the location, size, and depth of the wound, along with the patient’s medical history, pain tolerance, and any pre-existing conditions.
Vitamin E and wound healing
Wound healing is a complex and dynamic process that involves various cellular and molecular mechanisms to restore tissue integrity and function. Vitamin E, with its antioxidant properties, helps modulate this inflammatory response, reducing excessive oxidative stress and promoting a balanced healing environment.
Vitamin A and wound healing process
Vitamin A is a fat-soluble vitamin that exists in two main forms: retinoids, which include retinol, retinal, and retinoic acid; and carotenoids, which are provitamin A compounds found in certain fruits and vegetables. Vitamin A plays a critical role in modulating the immune response by promoting the differentiation and maturation of these immune cells
Marjolin’s ulcers
Marjolin’s ulcers are a specific type of squamous cell carcinoma (SCC), a common form of skin cancer.
Incontinence and dermatitis
Incontinence refers to the involuntary loss of urine or feces, while dermatitis refers to the inflammation of the skin. The association between these two conditions is primarily observed in the context of incontinence-associated dermatitis (IAD) or moisture-associated skin damage (MASD)
The antimicrobial resistance on wound management
Wound infections are common complications that can arise from injuries, surgeries, or chronic conditions. The emergence of antimicrobial-resistant pathogens poses significant challenges to effective wound management, potentially leading to severe consequences for patients
Pressure injury prevention
Pressure injuries are a significant healthcare concern affecting a wide range of individuals, particularly those with limited mobility or who spend extended periods in bed or chairs. Pressure injury prevention is a multifaceted endeavor that requires a collaborative effort from healthcare professionals, caregivers, and patients alike
Scleroderma ulcer
Scleroderma is a rare and complex autoimmune disease that affects the connective tissues in the body, leading to excessive collagen production and skin thickening. One of the most distressing complications associated with scleroderma is the development of scleroderma ulcers
Classification of the burn
Burns are injuries to the skin and underlying tissues caused by exposure to heat, chemicals, electricity, or radiation. Early and accurate classification of burns enables healthcare providers to offer timely interventions, manage pain, prevent complications, and support the healing process, improving the overall prognosis for burn victims.
The Therapeutic Potential of Silicone Gel for Scar Tissue Management
Scar tissue, a natural part of the body’s healing process, can form after various types of injuries, surgeries, or skin conditions. Silicone gel, an innovative and non-invasive solution, has gained popularity as an effective approach to manage and improve the appearance and texture of scars
The Significance of Debridement in Wound Care
Debridement is a crucial aspect of wound care. One of the primary reasons debridement is vital in wound care is its ability to facilitate the healing process. debridement is an indispensable aspect of wound care that significantly impacts the healing process and patient outcomes. Its ability to remove devitalized tissue, foreign debris, and biofilm from wounds creates a favorable environment for cellular repair and minimizes infection risks
The Versatile Role of Silver in Wound Infection Management and Prevention
From ancient civilizations to modern medicine, silver has played a significant role in wound infection management and prevention. In recent years, advancements in research and technology have unveiled the full potential of silver-based treatments, making it a crucial component in wound care.
Pressure injury classification
Pressure injuries, also known as pressure ulcers or bedsores, are localized damage to the skin and underlying tissue, primarily caused by prolonged pressure on specific areas of the body. Pressure injury classification is a critical aspect of healthcare that plays a significant role in patient care, prevention, and treatment.
Diabetic Foot Ulcer Prevention Strategies
Diabetic foot ulcers are a common and serious complication of diabetes that can lead to significant morbidity and even amputation if not properly managed. Prevention is crucial in reducing the incidence of diabetic foot ulcers and improving the quality of life
Biofilm and Inflammation in Wound Healing
Biofilms are structured communities of microorganisms encased within a self-produced matrix, and their presence in wounds poses a significant challenge to effective wound management. The biofilm matrix, primarily composed of polysaccharides, proteins, and extracellular DNA, acts as a protective shield for the microorganisms, rendering them highly resistant to antimicrobial agents and the host immune response
Wound Bed Preparation Enhancing Healing and Promoting Optimal Outcomes
Effective wound bed preparation aims to remove barriers to healing, promote tissue regeneration, and ultimately accelerate the wound healing process. wound bed preparation is a comprehensive and dynamic process that involves the systematic assessment, debridement, cleansing, and management of underlying factors to promote optimal wound healing
Compression Therapy: Indications and Types
Compression therapy is a widely used medical treatment for various conditions involving the circulatory and lymphatic systems. It is a valuable medical intervention with a wide range of applications. From managing chronic conditions like venous insufficiency and lymphedema to preventing DVT during travel, compression therapy offers numerous benefits.
Enzymatic Debridement An Effective Approach to Wound Healing
Debridement, the removal of necrotic (dead) tissue, is a critical step in wound management to promote faster healing and reduce the risk of complications. One method gaining increasing recognition for its efficacy is enzymatic debridement.
Cytotoxicity in Wound Care Is Silver Safe?
The use of silver-based products has become increasingly popular due to their broad-spectrum antimicrobial properties. Silver-based products have shown significant promise in wound care due to their potent antimicrobial properties. The key lies in finding the right balance between the benefits and risks of using silver in wound care
The Use of PHMB in Wound Care A Powerful Antimicrobial Agent
The use of polyhexamethylene biguanide (PHMB) has gained significant attention in wound care due to its potent antimicrobial properties and numerous benefits. (PHMB) has emerged as a powerful and effective antimicrobial agent in wound care. Its broad-spectrum activity, low cytotoxicity, and ability to disrupt biofilms
The Use of Iodine Dressing in Wound Care: Benefits and Considerations
Iodine has been utilized in medicine for centuries due to its remarkable antiseptic properties, and its role in wound care continues to be significant. iodine dressing is a valuable tool in wound care due to its antiseptic properties, wound debridement capabilities, and broad applicability.
Periwound Management
Periwound refers to the area surrounding the wound site, and proper management is essential for optimizing the healing process and preventing complications. Effective management of the periwound area is vital for promoting wound healing, preventing complications, and ensuring better patient outcomes.
Manuka honey wound dressing
Manuka honey has emerged as a potent wound dressing with remarkable therapeutic properties. It contains a higher concentration of bioactive compounds, primarily methylglyoxal (MGO), which gives Manuka honey its potent antibacterial properties.
Granulox as Topical Oxygen Therapy A Revolutionary Approach in Wound Healing
Topical oxygen therapy has emerged as a promising solution to promote wound healing and expedite the recovery process
Choosing Antimicrobial Wound Dressings
Antimicrobial wound dressings play a vital role in preventing and treating infections, promoting faster healing, and improving patient outcomes. Choosing the appropriate antimicrobial wound dressing requires a comprehensive assessment of the wound, infection severity, patient history, and overall treatment plan
Negative pressure
Negative pressure wound therapy (NPWT) is a clinically proven and widely utilized technique in modern wound care. It involves the application of sub-atmospheric pressure (negative pressure) to a wound to promote healing and accelerate the recovery process.
What You Need to Know About Pilonidal Cysts
A pilonidal cyst is a relatively common but painful condition that can affect individuals of all ages. It is a cyst that forms at the base of the tailbone (coccyx) or in the crease between the buttocks. Pilonidal cysts can manifest in various ways, and symptoms
Surgical Site Infection in Orthopedic Surgery Prevention and Management
Orthopedic surgery plays a crucial role in treating musculoskeletal disorders, injuries, and joint replacements, significantly improving patients’ quality of life. However, surgical site infections (SSIs) can be a serious complication that leads to increased morbidity, prolonged hospital stays, and increased healthcare costs.
Collagen Dressings in Wound Care A Revolutionary Approach
Collagen, a vital protein in the body, plays a crucial role in tissue repair and regeneration. In wound care, the use of collagen dressings involves incorporating this protein into dressings to facilitate the healing process.
The Baux score for burn
Baux index, is a numerical assessment used in medicine to predict the prognosis and mortality risk of burn patients. The Baux score takes into account three critical parameters: the patient’s age, the percentage of total body surface area (TBSA) affected by burns, and the presence or absence of inhalation injury.
Pressure Injuries
Pressure injuries are a significant health concern that affects millions of people worldwide, particularly those with limited mobility or chronic medical conditions.
Charcot foot
Charcot foot is a serious and potentially debilitating condition that affects the bones and joints of the feet, primarily in individuals with diabetes. Several risk factors can contribute to the development of Charcot foot, including long-standing diabetes, poorly controlled blood sugar levels, peripheral neuropathy, peripheral arterial disease (poor blood flow).
Lower Extremity Wounds
Lower extremity wounds are a significant health concern that affects millions of people worldwide. They can result from various causes, such as accidents, trauma, chronic medical conditions, and infections. Managing and treating lower extremity wounds is essential to prevent complications, reduce morbidity, and improve the quality of life for affected individuals.
Management of Severe Burns
Severe burns are among the most devastating and life-threatening injuries that a person can experience. The management of severe burns is a complex and multifaceted process that requires prompt and efficient intervention to improve patient outcomes and minimize complications.
Advanced Wound Care Dressings Revolutionizing Wound Healing
These innovative products have revolutionized the way healthcare professionals treat various types of wounds, ranging from minor cuts and burns to complex chronic ulcers. Advanced wound care dressings offer superior benefits over traditional dressings, promoting faster healing, reducing the risk of infection, and improving patient comfort.
Role of the Vitamin C in wound healing
Wound healing is a complex physiological process that involves multiple cellular and biochemical events to repair damaged tissue and restore the body’s structural integrity. Vitamin C plays a crucial role in promoting and accelerating the regenerative process.
Debridement and wound care
Wound debridement is a important medical procedure performed to promote efficient wound healing. Different type of debridement can be perfomed (surgical and mechanical Debridement, Autolytic or Enzymatic Debridement). wound debridement is the key in the management of various wounds, assisting the body’s natural healing process and reducing the risk of complications
Dr Sergio Mazzei on Porta a Porta
Dr. Sergio Mazzei, an esteemed Italian doctor in Dubai, shares his insights and experiences in an exclusive interview on Porta a Porta.
Antimicrobial polymer PHMB
The broad-spectrum antimicrobial biocide polyhexamethylene biguanide (PHMB; polyhexanide) kills bacteria, fungi, parasites and certain viruses with a high therapeutic index. Kantaraja Chindera and Coll. conducted this study in which they showed how the PHMB can work.
Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot
Diabetes is a disease in which patients have high level of sugar in blood. 15% to 25% of people with diabetes develop a foot ulcer in their lifetime. A multidisciplinary team from Health Quality Ontario performed this study in which they evaluated standard wound care plus hyperbaric oxygen therapy results in an improvement in ulcer healing compared with standard wound care alone.
Effects of Moist Exposed Burn Therapy and Ointment (MEBT MEBO)
The treatment for diabetic ulcer wounds is a challenging. Many studies proved that MEBT/MEBO could promote ulcer wound healing in diabetic rats.
Multidisciplinary approaches for the prevention and management of diabetic x disease – Guidelines
Diabetic foot disease is the most common cause of hospitalization for diabetes. Patients with diabetic foot have a higher risk of amputation and death, and thus it is important to standardize their diagnosis and treatment.
Clinical Efficacy of Acellular Dermal Matrix Paste in Treating Diabetic Foot Ulcers
More than 150 million people worldwide suffer from diabetes, and every patient with diabetes is at risk of developing a diabetic foot ulcer (DFU). Recent studies have explored more effective wound dressings and tissue engineering techniques. Clinical studies have already documented the safety and efficacy of ADM in chronic wound healing
Laser Therapy Induces Increased Viability and Proliferation in Isolated Fibroblast Cells
Laser therapy (LT) applications have been used for many years in the field of dentistry and oral surgery for the treatment of pain relief and wound healing. Laser therapy has been reported to increase ATP, accelerate mitosis, improve tissue repair, stimulate bone repair, normalize collagen and elastic fibril accumulation in tissue repair, stabilize fibroblast production, increase peripheral blood flow, and improve anti-inflammatory activity
Management of the Peri Wound Skin
The skin surrounding the injury is called ‘Periwound’. it can become macerated which is vulnerable to breakdown, leading to a possible increase in the size of the wound. In such a situation, ‘Periwound Skin Management’ plays an imperative role.
Efficacy of a Urinary Bladder Matrix for Treating Wound Dehiscence With Hardware Exposure in a Patient With Rheumatoid Arthritis
This case report explores an effective treatment modality in a medically complicated patient with wound dehiscence of the right great toe and subsequent exposure of surgical hardware, complicated by infection treated Urinary Bladder Matrix (UBM).
Topical Oxygen and Hyperbaric Oxygen Therapy Use and Healing Rates in Diabetic Foot Ulcers
Oxygen delivery is a crucial element involved in wound healing and it is widely recognized that limited oxygenation can lead to a chronic nonhealing ulcer. A retrospective review comparing healing rates of diabetic foot ulcers utilizing Hyperbaric Oxygen Therapy (HBOT) or Topical Oxygen Therapy (TOT) was performed.
Maggot Debridement
A wound is a break or damage in the surface of the skin and it can be accidental as well as surgical. Debridement plays an imperative role in healing a complicated injuries. There are various methods that are available and Maggot Debridement could be one of this. Maggot therapy is a type of biotherapy involving the introduction of live, disinfected maggots (fly larvae). The flies used most often for the purpose of maggot therapy are blow flies of the Calliphoridae: the blow fly species used most commonly is Lucilia sericata, the common green bottle fly.
It is an effective technique for debriding wounds that was used especially in the previous centuries.
Ingrown toenail
Reportedly about 20% of people who visit a doctor for advice regarding a foot problem have an ingrown toenail. The most common cause of an ingrowing toenail is not cutting your toenails properly, by cutting them too short or down the sides of your toenail, and wearing shoes which are not wide enough to fit your toes in their natural position.
The use of biosynthetic polimer from sugar cellulose for second degree burn
This is the presentation about the use of biosynthetic polimer from sugar cellulos for the second degree burn at the 14th Abu Dhabi wound care conference on March 2023.
Clinical Effectiveness of Hemoglobin Spray as Adjunctive Therapy in wound care
This is my last presentation at the 14th Abu Dhabi wound care conference on March 2023. It was presented the effectiveness of the use of Heamoglobin Spray in wound care.
Human derived Acellular Dermal Matrix Grafts for Treatment of Diabetic Foot Ulcers. A Systematic Review and Meta-analysis
Diabetes affects more than 22 million people in the United States and Foot wounds are a common complication associated with diabetes mellitus (DM) and often impose significant economic, health, and quality of life.
Oxygen in Wound Healing
Oxygen is a significant factor in wound healing. In normal wound healing, the wound either requires conditions of hypoxia or normal levels of oxygen (ie, normoxia). Wound healing might be delayed in extreme hyperoxia which can cause growth arrest and cell death by mitochondria apoptosis. This study clarified that 1) oxygen is needed for mitochondrial cytochrome oxidase 2) oxygen is also involved in collagen maturation, 3) hypoxia is required to start the process of wound healing, 4) superoxide ion kills bacteria, and 5) hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers, crush injuries, and soft-tissue infections could help the wound healing.
T.I.M.E wound assessment
Injuries are considered to be acute if they are new while more than 3 or 4 weeks old wounds are chronic. TIME Wound Assessment is a unique and significant systematic approach to wound healing that involves eliminating non-viable tissue, restoring moisture balance, controlling infection, and promoting epithelial advancement. It is not a sequential process since every wound is different. The ‘TIME’ acronym, consisting of tissue debridement, infection or inflammation, moisture balance and edge effect, has assisted clinicians systematically in wound assessment and management.
Treatment of Frostbite With Hyperbaric Oxygen Therapy: A Single Center’s Experience of 22 Cases
Hyperbaric oxygen therapy (HBOT) treats patients with 100% oxygen at greater than 1.0 atmosphere (atm). This is the largest series (22 cases) in the literature of patients with frostbite treated with HBOT as an adjunct to wound care.
Pain, Psychological Comorbidities, Disability and Impaired Qualify of Life in Hidradenitis Suppurativa
Hidradenitits suppurativa (HS) is a chronic, painful inflammatory skin disease characterized by recurrent inflammatory nodules and abscesses. The main factors that impact quality of life (QoL) will differ for each patient, but commonly include limitation of daily activities.
Negative Pressure Wound Therapy With Instillation and a Reticulated Open Cell Foam
Wound healing can be impaired by systemic factors and local factors. Dr W Cole conducted a retrospective assessment of 10 patients (N = 10) with complex lower extremity wounds treated with either advanced wound dressings (control group; n = 5) or NPWTi-d using ROCF-CC dressings (treatment group; n = 5) that was performed between June 2015 and October 2017 at Cleveland center – Ohio.
Hidradenitis Suppurativa: a Cochrane systematic review
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that affects apocrine gland-bearing skin in the axillae, groin, and under the breasts. It is characterised by persistent or recurrent boil-like nodules and abscesses that culminate in a purulent discharge, sinuses, and scarring
Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus
Foot ulcers in people with DM have a serious impact on health, related with the quality of life, particularly with respect to physical functioning and role-limitations due to physical and emotional issues. Any intervention that promotes healing makes an important difference. The Cochrane review about the use of Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus make analysis about the use of it.
Vasculogenic Chronic Ulcer Tissue Regeneration with an Innovative Dermal Substitute
Vasculogenic ulcers (venous, arterial, and/or both) are the most common type of ulcers in the legs. De Angelis and coll conducted this study, 35 patients affected by vasculogenic chronic ulcers localized on the inferior limbs with the application of collagen dermal substitute template. followed by the autologous dermal-epidermal graft (DEG).
Methicillin-resistant Staphylococcus aureus an overview of basic and clinical research Comparison
MRSA colonization increases the risk of infection, and infecting strains match colonizing strains in as many as 50–80% of cases.
The Risk of Infection and Indication of Systemic Antibiotics in Chronic Wounds
Chronic wounds are associated with a significant increase in health care utilization and health care costs,3 increased morbidity and mortality. Can the Wounds at Risk (WAR) score help to assess the risk of infection in patients by scoring several host factors that can contribute to an increased risk for infection in wounds?
Dehydrated human umbilical cord biological properties for wound care and soft tissue healing
Chorion-amniotic membranes are widely accepted as a therapeutic option for the healing of cutaneous wounds due to their immunologically privileged status and bioactive properties.
An Overview and Significant Benefits of Shock Waves Therapy in the Wound Healing
Shock Waves Therapy in the Wound Healing works by triggering the regeneration potential of cells present in the body. Therefore, shockwaves have persistently proven to be an effective treatment for a wide range of painful injuries and conditions.
Advances of Stem Cell Therapeutics in Cutaneous Wound
The skin wound might be of different nature and varies from surgical to accidental lacerations, burns, pressure ulcers, diabetic ulcers, and venous ulcers. Mesenchymal stromal cells, also known as mesenchymal stem cells (MSCs), are adult stem cells capable of self-renewal and multipotential differentiation. MSC transplantation led to accelerated cutaneous wound closure. the mechanisms by which these stem cells contribute to the healing process have yet to be elucidated
Skin Condition in Elderly and Geriatric Patient
As we age, our epidermis undergoes several changes. The key characteristics of geriatric sufferers are advanced age, a decrease in physical performance, care dependency, and multimorbidity. In addition, this stage of life leads either directly or indirectly, to a wide range of skin as well as tissue problems.
Lymphedema of the lower limb and its complications and solutions
A long-term condition that affects one of the legs or arms. In a few cases, both legs and arms may be affected.
Hyaluronic Acid and Re-epithelialization
Hyaluronic acid (hyaluronan, HA) is a large glycosaminoglycan and an essential extracellular component of skin It is active throughout the entire process of wound healing being involved in proliferation, migration, and tissue remodelling. Erika Nyman published on 2019 this interesting study in which he investigated the influence of exogenous HA on re-epithelialization, erythema, and protein expression. Nyman and Coll concluded that exogenous intradermal HA accelerates re-epithelialization and alters protein expression in human in vivo deep dermal skin wounds.
PRP Application prior to Resurfacing with Split Thickness Skin Graft Vs Conventional Mechanical Fixation Using Sutures and Staples
A split-thickness skin graft is generally done for soft skin coverage. The healing process is undertaken through three stages anchorage, inosculation and maturation. Subha Dhua and colleagues conducted this Randomized control study on 40 patients for 24 months from October 2015 to September 2017. The application of autologous platelet-rich plasma (PRP) to the split-thickness skin graft sites is considered and theorized to provide immediate skin graft anchorage.
Surgical treatment of venous insufficiency
Venous insufficiency is a condition that occurs when valves within the leg veins are damaged allowing blood to leak backwards and pool in these veins.
Superficial Burn Wound Healing with Intermittent Negative Pressure Wound Therapy
Thermal burn initiates systemic inflammatory reactions producing burn toxins, oxygen radicals and finally leads to peroxidation. Negative pressure wound therapy (NPWT) is a non-invasive adjuvant therapy to treat burn wounds.
Staphylococcus aureus Infections Epidemiology, Pathophysiology, Clinical Manifestations and Management
Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. Steven Y.and coll conducted this study to summarize recent developments in the epidemiology, pathophysiology, clinical manifestations, and management of these key S. aureus clinical infection syndromes.
Biobrane dressing for pediatric burns in Singapore. A retrospective review
Cong Fan and colleagues conducted a retrospective review about pediatric burns patients admitted to the pediatric burns unit from January 2014 to April 2015 at Singapore General Hospital, Singapore. This study aimed to compare the results of Biobrane dressing with conventional silver foam dressing. In the Biobrane group, the length of hospital stay was significantly shorter and the infection rate was significantly lower
The benefit of debridement
The scope is to remove the damaged and dead tissue to remove the death tissue and bacteria from the wound, minimising infection risk and encouraging healthy granulation tissue.
Chronic Wound. What you have to know
A chronic wound is an injury that doesn’t heal in six weeks. Factors that contribute to chronic wounds include increased bacterial load, inappropriate treatment, trauma, lower extremity wounds, senescent/aberrant cells and so on
Edema of the skin. Cause and treatment
Edema is swelling that occurs in different areas of the body when too much fluid gets trapped in the tissues. It often takes place in the epidermis, particularly on the legs, feet, ankles, arms, and hands.
Management of surgical wound infection
SSI is an infection related to a surgical procedure that occurs near the surgical site within 30 days following surgery
Dressings and topical agents to treat the pressure ulcers
Bedsores (also called pressure ulcers or decubitus ulcers) are injuries of the skin and underlying tissue, resulting from prolonged pressure on the skin. Westby MJ and Coll have successfully conducted a network meta-analysis of dressings and topical agents for healing pressure ulcers. This review includes 51 RCTs involving a total of 2964 participants, comparing 39 different dressings or topical agents for the healing of pressure ulcers.
Prevention of diabetic wound ulcer
Diabetes mellitus, commonly known as diabetes, is a metabolic disease that causes high blood sugar. Untreated high blood sugar from diabetes can damage your nerves, eyes, kidneys, and other organs.
Silver foam dressing and zinc-hyaluronic gel for the treatment of partial thickness hand burn injuries
The hydrofiber dressing consists of a superficial polyurethane waterproof layer and a multilayered absorbent surface containing 1.2% ionized silver. Zinc-hyaluronic acid promotes cell regeneration.
Gergo Jozsa conducted this study in which 37 children were treated conservatively with a special dressing at first intervention containing Hydrofiber dressing with silver foam and Zn-hyaluronic gel to determine their effectiveness on partial-thickness hand burns.
Dressings for the prevention of surgical site infection (Review)
In the UK it has been estimated that 4% to 5% of patients undergoing a surgical procedure contract an SSI. Dumville JC and Coll conducted this review, including 29 trials (5718 participants). The scope of the work was to compare Dressings for the prevention of surgical site infection.
Smoking and wound healing
Oxygen is the basis for wound healing, and it begins at the cellular level. Smoking deprives the body of the oxygen it needs to repair wounds and build new tissue. not many people know that smoking also slows down the healing process.
Lymphatic System and Wounds
The ‘Lymphatic System’ is a complex network of tissues & organs that play an imperative role in homeostasis of extracellular space. Patients suffering from lymphedema have increased the risk of wound formation.
Dehydrated human amnion/chorion membranes and wound healing
Wound healing is a well-coordinated sequence of events in which signalling and remodelling of the extracellular matrix (ECM) are integral components. dehydrated human amnion/chorion membrane (dHACM) has demonstrated clinical efficacy in the enhancement of wound repair compared with standard compression therapy.
Comparison of Efficacy and Complications Between Negative Pressure Wound Therapy and Conventional Mechanical Fixation in Skin Grafts: A Retrospective Analysis.
Negative-pressure wound therapy (NPWT) is a therapeutic technique using a suction dressing to remove excess exudation and promote healing in acute or chronic wounds and second-and third-degree burns. Negative pressure could be utilized to secure a skin graft, improving the drainage. Shen X and Coll conducted this retrospective study in which they evaluated 186 patients
Most Common Chronic Wound
A chronic wound is an injury type that develops when an acute wound fails to heal in the expected time. It might be a couple of weeks or six weeks in a few cases. The conditions that stop or slow the healing process may lead to similar illnesses are infection, weak immune system, poor blood supply & low oxygen and so on.
Bioresorbable scaffold as a dermal substitute
Burns, trauma, chronic and complex wounds can result in complete loss of skin, leading to infection, increased insensible water loss, hypothermia, difficulties in patient management. Lenon Cardoso and Coll performed this study to assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats.
Wound Care and peri wound area
A chronic wound is a lesion that doesn’t heal in a specific time but shows delayed wound healing. Many factors could lead an acute wound to become a chronic wound such as diabetes with its complications, low blood flow, soft tissue infection and so many other conditions.
The use of porcine urinary bladder matrix in wound care
It was a pleasure to be a speaker at the 6th Emirates Plastic Surgery Congress in Dubai. You could have a look at the topic ”the use of porcine urinary bladder matrix in wound care”
Silver Dressing
Silver has broad-spectrum antimicrobial properties against a wide spectrum of gram-positive and gram-negative bacteria. The use of Silver dressings is recommended for acute or chronic wounds with, or at risk of, a high level of bioburden or local infection.
Skin Assessment
The skin has various significant functions including prevention of loss of body water, temperature control, protection from harmful microbes & substances, and temperature control. Skin Assessment is a process in which the entire skin of a sufferer is examined for abnormalities.
Ingrowing toenails in children and adolescents
An ingrown toenail, also known as onychocryptosis, occurs when the nail plate grows into the adjacent periungual skin and acts as a foreign body, causing inflammation and infection. Sumanth Kumar Gera conducted this study to compare the results of nonoperative treatment for IGTN with that of operative treatment among children and adolescents. This study aimed to compare the results of nonoperative treatment for IGTN with that of operative treatment among children and adolescents.
Skin tissue engineering – stem cell and wound healing
The approach of regenerative medicine has emerged as an alternative to provide additional therapeutic options to potentially improve wound healing.
Hyperbaric Oxygen Therapy Effects on Chronic Wounds
Hyperbaric oxygen therapy (HBOT) delivers 100% inspired oxygen to individuals at 2.0 to 2.5 absolute atmospheres (ATA) of pressure for a typical total duration of 60-120 minutes during 1-2 daily sessions inside a hyperbaric chamber. Laura Bolton conducted a systematic review of randomized clinical trials (RCTs) comparing HBOT effects on chronic wounds to those of another therapeutic regimen.
Complication of Venous Ulcers
Ulcers are open skin sores that can affect any area of the epidermis and they most often occur on the legs due to problems with blood circulation in the veins.
Cells involved in regeneration dermis
The dermis is the mesenchymal component of the skin, separated from the epidermis by the basement membrane. . The dermis comprises two structurally different layers named the papillary and reticular layer. Alexandra L. Rippa and Coll published this scientific article about the different steps of the wound healing and which cells are involved in the healing process.
Bone infection: Osteomyelitis
A Bone Infection can result when fungi or bacteria invade a bone. It can either develop suddenly or over a long period. The first and foremost Symptom of the same is pain at the infection site.
Contact Dermatitis
Contact dermatitis is an itchy and red rash that crops up on your epidermis when you touch or have a reaction to a few substances. Contact Dermatitis is caused by a substance you are exposed to which either irritates your skin or triggers an allergic reaction.
Burns
A burn is tissue damage that results from scalding, overexposure to the sun or other radiation, contact with flames, chemicals or electricity, or smoke inhalation.
Prevention of Postoperative Wound infection
Surgical site infection (SSI) may occur in 5–20% after surgery. Up to 60% of SSI can be prevented. Bjørg Marit Andersen made an interesting scientific article about the prevention of postoperative wound infection.
Human Amniotic Membrane and Wound Healing
Human amniotic membranes (hAMs) have shown promising results in recent studies aimed at improving wound healing. Ben Samuel John and Coll conducted a study on the 2019 full-thickness skin defects in 4 groups of 6 rats with one wound each.
Bacterial Wound Colture
Wound assessment of a wound is a breakdown in the protective function of the epidermis. If it becomes infected, it can get worsen instead of better. Bacterial Wound Colture is a test to identify harmful bacteria that may be growing in the injury. the type(s) of germ detected is afterwards subjected to sensitivity/susceptibility testing. the final outcome allows clinicians to make a wise decision about the appropriate therapy to inhibit the growth of the bacterium.
Surgical Site Infection
SSI stands for Surgical Site Infection, an infection that occurs after surgery in the part of the body where the surgery took place. About 1 to 3 out of every 100 patients develop some infection after the surgical intervention.
Pressure Injury and Oral Supplement
Pressure Injury is an area of the injured epidermis. It happens when force is applied to the outermost layer of the skin, especially over the bony body parts. The inadequate diet intake, low body mass index, and presence of malnutrition have been acknowledged as the pivotal risk factors for both the delayed wound recovery and development of pressure injuries. An adequate amount of right supplements could be required for these patients.
The use of Extracorporeal Shockwave Therapy for Chronic Diabetic Foot Ulcers
Etiologies of chronic diabetic foot ulcers (DFUs) are multifactorial. They are caused by angiopathy and poor skin sensation due to peripheral neuropathy.
Chou WY conducted this study at Kaohsiung Chang Gung Memorial Hospital (Kaohsiung, Taiwan). During the course of study, a total of 21 patients were screened. Extracorporeal shockwave therapy was shown to induce neovascularization and increase angiogenic and osteogenic growth factors that lead to improvement in blood flow perfusion and tissue regeneration.
Ingrown nails – causes and treatment
A discussion about the causes and treatment of ingrowing nails. Have a look of my contents in the Al Das Medical Clinic web site.
Deep Venous Thrombosis And Doppler Ultrasound
Deep Venous Thrombosis is a condition where blood clots form in the vein deep in your body, often in your legs. Oedema, leg pain, the warmth of the skin over the area of thrombosis are the most common clinical sign and symptoms.
Negative pressure and natural porcine extracellular matrix in stage 4 pressure injuries
Walid Mari and Coll conducted a prospective, multicentered, randomized, controlled, single-blinded clinical trial from August 2014 to June 2016 about the use of negative pressure and natural porcine extracellular matrix in stage 4 pressure injuries.
Collagen Dressing in Burn
A discussion about the use of dermal substitutes collagen made for the treatment of burn. Have a look of my contents in the Al Das Medical Clinic web site
Bandage the Leg Ulcers
Leg Ulcer is an open wound or a sore on the legs. they are more common in females but can affect both women and men of any age. It is necessary to have assessment before performing the bandage. Several clinical conditions could cause leg ulcers. Usually a graduated external compression plays a major role in the successful treatment for lower limb open wounds, especially for the treatment of venous ulcers.
The Healing Effect of Sesame Oil, Camphor and Honey on Second Degree Burn Wounds in Rat
An interesting scientific publication Reza Vaghardoost and Coll. A study was conducted in which they evaluated herbal ointment (composed of sesame oil, camphor and honey) to treat a second degree burn wound.
Biofilm and Wound Healing: An Overview, Causes, and Treatment Methods
Biofilms are dynamic communities of bacterias. Biofilm in injury is a type of contamination made up of living microorganisms which are capable of forming colonies. If a patient has treated for the non-healing chronic wound which failed to progress, they are most likely dealing with a Biofilm. Topical agents including Creams, Methylene Blue, and Cadexomer iodine also help eradicate the Biofilm.
Managing Wounds as a Team
Only minor injuries can be treated at home through medications & natural remedies. But, in case of wounds which involve skin and subcutaneous tissues, muscular fascia or bones, you need to look for immediate medical attention.
The use of Efficacy of Cadexomer Iodine in the Treatment of Chronic Ulcers
With the emergence of multidrug-resistant strains of organisms and a better understanding of the dynamics of wound healing, there has been an interest in topical use of iodine in wound care.
Dehydrated human amnion/chorion membrane treatment of venous leg ulcers
Another scientific publication about a clinical case at Al Zahra Hospital Dubai, using Dehydrated human amnion/chorion membrane for the treatment of venous leg ulcers.
Topical Antibiotic in the Wound
“Topical Antibiotics” are medicines in the form of cream & ointment applied directly to the skin for destroying or inhibiting the growth of susceptible bacteria. The primary role of “Topical Antibiotic” is to reduce the microbial contaminant exposure after the surgery.
Modalities of wound Debridement
This is my last presentation at the 5th Emirates Plastic Surgery Congress in Dubai in January 2020. Debridement as the first step for wound healing.
Innovation in wound care
This is the second of three presentations that I had at the 5th Emirates Plastic Surgery Congress in Dubai in January 2020. It describes the use of dermal substitutes and tissue engineering in wound healing.
Beauty in wound care
This is the first of three presentations and it describes the use of advanced dressing in the clinical practice.
The use of Hydrocellular Foam Versus Hydrocolloid Plate in the Prevention of Pressure Injuries
An interesting scientific publication by Fabiana da Silva Augusto and Coll conducted single-center case series from April 2012 to July 2013, comparing the use of hydrocellular foam and hydrocolloid plate dressings on the prevention of bedsores.
HBOT Symposium 2019
I had my talk during 2nd Al Zahra Hyperbaric Oxygen therapy Symposium. Many thanks to Al Zahra Hospital Dubai for the opportunity and the continuous support!
Major Vitamins That Facilitates the Wound Healing Process
Nutritional status of patients at the time of trauma influences the biochemical processes necessary for the phases of normal healing to occur
To heal them properly, all you need is to undergo an effective treatment method. Also, it’s pivotal to maintain healthy levels of “Vitamins” like A, B, C, E and other nutrients.
Use of human acellular dermal matrix for wound healing in a patient with necrotizing fasciitis
This is a clinical case using hADM to close an open wound of the right foot caused by the penetration of part of a shell into the skin followed by necrotizing fasciitis, after multiple unsuccessful treatments using Negative Pressure Wound Therapy, porcine acellular dermal substitutes and a split-thickness skin graft.
An Overview on Wound Bed Preparation and the TIME Framework
“Wound Bed Preparation” has become a standard model that allows physicians to identify and breakdown local barriers for healing the injury. It’s a complex process that can be impacted by an array of significant factors. In addition, it usually progresses through various phases…
Arianna Fallacara 2018 – Hyaluronic Acid in the Third Millennium
Hyaluronic acid is a natural polymer. In the human body, it is distributed around cells and in the extracellular matrix (ECM). A Fallacara and Coll conducted an interesting overview, describing the history, physicochemical, structural and hydrodynamic of hyaluronic acid. They evaluated also the different applications of the HA in medicine, pharmaceutical and cosmetic fields.
Venous Ulcers
Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the legs. They are the major occurrence of chronic wounds, occurring in 70% to 90% of leg ulcer cases. Venous ulcers develop mostly along the medial distal leg and can be painful with negative effects on quality of life.
Hyperbaric Oxygen Therapy as an Adjunctive Therapy for Wound Care
Hyperbaric oxygen therapy (HBOT) is an of treatment in which a patient breathes 100% oxygen at a pressure greater than 1 atmospheric pressure (ATA) in a chamber. The aim of the treatment is to increase the O2 level dissolved in the plasma up to 15 times the normal amounts, which helps in the treatment of many diseases.
Human amnion/chorion membrane allograft in the management of diabetic foot ulcer
An interesting scientific publication by Dr. Tettelbach and Coll who conducted a prospective, randomized, controlled and multicentre clinical trial. The scope of this study was to evaluate the healing outcomes in diabetic patients with chronic lower extremity ulcers treated with a weekly application of dHACM.