Hyaluronic acid ester matrix

The 3D hyaluronic acid ester matrix is a substitutive and regenerative matrix (dermal substitute) able to replace the dermis, providing a three-dimensional scaffold for cellular invasion and capillary growth. It is a bi-layer of an esterified hyaluronan scaffold. First top layer constitutes of a silicone membrane that works as a temporary barrier.

The second layer contains the hyaluronic acid that delivers hyaluronan to the wound bed. The dermal substitutes are applied to cover the tissue damaged for the wound treatment. The contact between the wound and the hyaluronic acid helps the wound healing process, facilitating an ordered reconstruction of the dermal tissue.

Extracellular matrix (ECM) is a tridimensional scaffold consisting of collagen, enzymes, and glycoproteins, providing support for the cells. Hyaluronic acid (HA; conjugate basehyaluronate) is one of the chief components of the ECM and it is widely distributed throughout connective, epithelial, and neural tissues. Hyaluronic acid contributes to cell proliferation and migration in the wound healing process. It plays essentials roles in the treatment of the wound, such as:

Guarantees a moist environment in the wound
Stimulates the proliferation of the new vessels
Helps cell proliferation and fibroblast migration
Stabilizes the new healthy tissue
Regulates the processes involved in the wound healing

Trauma, infection, tissue loss and so many other reasons can delay the wound closure. The use of dermal substitutes for the reconstruction with a dermal equivalent or dermal regeneration template is strongly required when standard treatment (advanced dressing for example) failed the wound healing or in the absence of autologous dermis.

The use of this dermal substitute to treat non wound healing is important because it can:

Provide the foundation for skin grafting and re-epithelialization
Reduce the risk of infection
Promote high quality of healing with elastic and no retractive scar

It has been used successfully in a different type of wounds for different clinical indications:

Pressure ulcers
Venous ulcers
Diabetic ulcers
Chronic vascular ulcers
Tunnelled/undermined wounds
Trauma wounds (abrasions, laceration skin tears, tissue damage)
Partial- and full-thickness wounds
Second-degree burns
Draining wounds
Surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric, wound dehiscence)

The only contraindications are linked with hypersensitivity to hyaluronan or silicone.