Naturally-occurring urinary bladder matrix

Naturally-occurring urinary bladder matrix is a dermal substitute that maintains and supports the healing environment, remodelling of site-appropriate and the functional tissue.

It is an acellular extracellular matrix graft derived from the inner lining of a porcine urinary bladder. It contains the epithelial basement membrane and collagen.

Collagens, glycoproteins, proteoglycans, mucins, elastic fibres, and growth factors and other factors make the three-dimensional network of extracellular macromolecules, called the extracellular matrix (ECM).

The use of the naturally-occurring urinary bladder matrix facilitates the repair process and remodelling the damaged tissue. It is available as a sheet or as a powder. The material goes through a complex process of decellularization, lyophilisation, disinfection, and terminal sterilization and before it is ready for use.

Application of dermal substitute is preceded by the following:

Treatment of infection. If clinical signs are present.
Cleaning of the wound bed, removing the slough and the exudates
Debridement procedure, removing any necrotic tissue
Use of the standard aseptic/sterile technique
Hydration of the dermal substitutes using sterile saline (0.9%) or sterile lactated Ringer’s solution prior to use.

Some clinical cases may require more than one surgical steps.

Naturally-occurring urinary bladder matrix (UBM) is intended for the management of woundsincluding:

Venous ulcers
Diabetic ulcers
Chronic vascular ulcers
Tunnelled/undermined wounds
Trauma wounds (abrasions, laceration skin tears, tissue damage)
Partial- and full-thickness wounds
Second-degree burns
Draining wounds
Surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)

There are only a few contraindications to use it:

Patient with known sensitivity or allergy to porcine materials
Third-degree burns