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Naturally-occurring urinary bladder matrix

Naturally-occurring urinary bladder matrix

Naturally-occurring urinary bladder matrix is a dermal substitute that maintains and supports the healing environment, remodelling of site-appropriate and the functional tissue.

It is an acellular extracellular matrix graft derived from the inner lining of a porcine urinary bladder. It contains the epithelial basement membrane and collagen.

Collagens, glycoproteins, proteoglycans, mucins, elastic fibres, and growth factors and other factors make the three-dimensional network of extracellular macromolecules, called the extracellular matrix (ECM).

The use of the naturally-occurring urinary bladder matrix facilitates the repair process and remodelling the damaged tissue. It is available as a sheet or as a powder. The material goes through a complex process of decellularization, lyophilisation, disinfection, and terminal sterilization and before it is ready for use.

Application of dermal substitute is preceded by the following:

  • Treatment of infection. If clinical signs are present.
  • Cleaning of the wound bed, removing the slough and the exudates
  • Debridement procedure, removing any necrotic tissue
  • Use of the standard aseptic/sterile technique
  • Hydration of the dermal substitutes using sterile saline (0.9%) or sterile lactated Ringer’s solution prior to use.

Some clinical cases may require more than one surgical steps.

Naturally-occurring urinary bladder matrix (UBM) is intended for the management of woundsincluding:

  • Venous ulcers
  • Diabetic ulcers
  • Chronic vascular ulcers
  • Tunnelled/undermined wounds
  • Trauma wounds (abrasions, laceration skin tears, tissue damage)
  • Partial- and full-thickness wounds
  • Second-degree burns
  • Draining wounds
  • Surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)

There are only a few contraindications to use it:

  • Patient with known sensitivity or allergy to porcine materials
  •  Third-degree burns