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Feb 24, 2020

Dehydrated human amnion/chorion membrane treatment of venous leg ulcers

Another scientific publication about a clinical case at Al Zahra Hospital Dubai, using Dehydrated human amnion/chorion membrane for the treatment of venous leg ulcers.

Venous leg ulcers are associated with important morbidities and worsen the quality of life of the affected individuals, as their healing is often a long and painful process. Therapeutic approaches include graduated compression, limb elevation, wound debridement and topical wound dressing. In patients affected by venous leg ulcers, human amnion/chorion tissue products have been evaluated. 13 Dehydrated human amnion/chorion membrane allograft is made up of multiple layers of epithelial cells and avascular connective tissue matrix. The purpose of our report is to show the safety and efficacy of dehydrated human amnion/chorion membrane in a 38yearold woman, diagnosed with systemic lupus erythematosus (treated with systemic glucocorticoid therapy) with nonhealing ulcers on the left leg. Slow healing and recurrence of venous leg ulcers cause disability and require continuous care, causing psychosocial and economic burdens. A correlation between intermediate wound reduction (40% of wound area reduction after 4 weeks of treatment) and complete healing at 24 weeks, in patients affected by venous leg ulcers was demonstrated. A recent literature review also demonstrated that patients treated with amniotic membrane products show better wound healing than patients treated with standard approaches, for burns, diabetic foot ulcers, fistulas, ocular defects and venous leg ulcers Evaluating new treatments based on dehydrated human amnion/chorion membrane could be a successful option to achieve the goal of a wound healing in a shorter time than standard approaches, as in our case.

Mazzei SSindoni AFama’ FBuizon NJShafei MA.
Indian J Dermatol Venereol Leprol.
2020 Jan 29. doi: 10.4103/ijdvl.IJDVL_175_19.

Source: https://www.ncbi.nlm.nih.gov/pubmed/31997789