Category: Dermal Substitutes

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Hyaluronic Acid and Re-epithelialization
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Hyaluronic Acid and Re-epithelialization

Hyaluronic acid (hyaluronan, HA) is a large glycosaminoglycan and an essential extracellular component of skin It is active throughout the entire process of wound healing being involved in proliferation, migration, and tissue remodelling. Erika Nyman published on 2019 this interesting study in which he investigated the influence of exogenous HA on re-epithelialization, erythema, and protein expression. Nyman and Coll concluded that exogenous intradermal HA accelerates re-epithelialization and alters protein expression in human in vivo deep dermal skin wounds.

Biobrane dressing for pediatric burns in Singapore. A retrospective review
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Biobrane dressing for pediatric burns in Singapore. A retrospective review

Cong Fan and colleagues conducted a retrospective review about pediatric burns patients admitted to the pediatric burns unit from January 2014 to April 2015 at Singapore General Hospital, Singapore. This study aimed to compare the results of Biobrane dressing with conventional silver foam dressing. In the Biobrane group, the length of hospital stay was significantly shorter and the infection rate was significantly lower

Dehydrated human amnion/chorion membranes and wound healing
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Dehydrated human amnion/chorion membranes and wound healing

Wound healing is a well-coordinated sequence of events in which signalling and remodelling of the extracellular matrix (ECM) are integral components. dehydrated human amnion/chorion membrane (dHACM) has demonstrated clinical efficacy in the enhancement of wound repair compared with standard compression therapy.

Bioresorbable scaffold as a dermal substitute
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Bioresorbable scaffold as a dermal substitute

Burns, trauma, chronic and complex wounds can result in complete loss of skin, leading to infection, increased insensible water loss, hypothermia, difficulties in patient management. Lenon Cardoso and Coll performed this study to assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats.

Arianna Fallacara  2018 – Hyaluronic Acid in the Third Millennium
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Arianna Fallacara 2018 – Hyaluronic Acid in the Third Millennium

Hyaluronic acid is a natural polymer. In the human body, it is distributed around cells and in the extracellular matrix (ECM). A Fallacara and Coll conducted an interesting overview, describing the history, physicochemical, structural and hydrodynamic of hyaluronic acid. They evaluated also the different applications of the HA in medicine, pharmaceutical and cosmetic fields.

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