Hyaluronic acid (hyaluronan, HA) is a large glycosaminoglycan and an essential extracellular component of skin It is active throughout the entire process of wound healing being involved in proliferation, migration, and tissue remodelling. Erika Nyman published on 2019 this interesting study in which he investigated the influence of exogenous HA on re-epithelialization, erythema, and protein expression. Nyman and Coll concluded that exogenous intradermal HA accelerates re-epithelialization and alters protein expression in human in vivo deep dermal skin wounds.
Tag: Dermal Substitute
Burns, trauma, chronic and complex wounds can result in complete loss of skin, leading to infection, increased insensible water loss, hypothermia, difficulties in patient management. Lenon Cardoso and Coll performed this study to assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats.
The approach of regenerative medicine has emerged as an alternative to provide additional therapeutic options to potentially improve wound healing.
Human amniotic membranes (hAMs) have shown promising results in recent studies aimed at improving wound healing. Ben Samuel John and Coll conducted a study on the 2019 full-thickness skin defects in 4 groups of 6 rats with one wound each.